QuickBiology News

In adult neurogenesis, there is very little knowledge about the embryonic origin and developmental process that leads to the establishment of adult neural progenitors in the mammalian brain. Scientists once thought that adult neurogenesis is from a specialized population of neural stem cells and they are different from the precursors generating neurons during embryo development. But a group of researchers from University of Pennsylvania, Philadelphia found that a single lineage of neural progenitors contributes to embryonic, early postnatal, and adult neurogenesis in the mice hippocampus.Read More

Eating habits is the critical aspect of our Healthy lifestyle. Balanced food choice (with different nutrients) over time will make good health of us. Recently, due to environmental pollution across the world, food safety is being increasingly scrutinized and questioned by the public. Read More

Next-generation sequencing (NGS), also known as high-throughput sequencing technologies allow us to sequence DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such have revolutionized the study of genomics and molecular biology.
Within the last 2–3 years, we have witnessed a rapid increase in quantity and quality in genomic and transcriptomic research that expands into other “-omics” fields. Technological changes allowed the expansion of our knowledge and changed views on bacterial genetics and biology.
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Scientists from Seattle and Berlin have published an atlas on mouse embryonic development. In their study the researchers examined about two million cells, with the RNA of each cell labeled individually with a specially developed method termed sci-RNA-seq. Junyue Cao, Malte Spielmann and their colleagues describe, which cell types differentiate between days 9.5 and 13.5 of mouse embryonic development, and how they transform into organs. In total, the scientists were able to identify 38 different main cell types and over 500 subtypes. In addition, they described 56 developmental trajectories in organ development for different cell types. The researchers compiled their results in an online atlas and made them accessible to the public.Read More

Obesity increases breast cancer (BC) risk in post-menopausal women by mostly unknown molecular mechanisms.
In this study, miRNA profiling by RNA-seq was performed in paired benign and malignant biopsies from 12 women at the extremes of the BMI distribution among 83 BC patients. Candidates were validated in all samples by qRT-PCR. Associations between miR-10b expression and validated target transcript levels, and effects of targeted manipulation of miR-10b levels in a primary BC cell line on proliferation and invasion potential, were explored.Read More