2019-05-30 by Quick Biology Inc.
Drug discovery is a critical element to ensure precision medicine. Next-generation sequencing (NGS) accurately track cellular behavior at the genomic, transcriptomic level, providing an efficient technology for drug screening. For instance, research uses NGS and identifies mutations associated with tumor types (Figure 1), then uses NGS again to screen ELT (DNA-Encoded chemical libraries) to discover drugs which inhibit or potentiate the effect the mutation (Figure 2).
Figure 1: Using NGS to identify target/biomarker (image from Ref1)
Figure 2: Using NGS to discover drug compound through ELT technology (image from Ref2)
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See resource:
1. Doostparast Torshizi, A. & Wang, K. Next-generation sequencing in drug development: target identification and genetically stratified clinical trials. Drug Discov. Today 23, 1776–1783 (2018).
2. Arico-Muendel, C. et al. Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series with In Vitro Replicon Activity. Antimicrob. Agents Chemother. 59, 3450–3459 (2015).